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KMID : 0613820070170070931
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Journal of Life Science
2007 Volume.17 No. 7 p.931 ~ p.936
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Effect of Codium Fragile Extract on Collagen Content and Collagen Cross-link Formation in Ovariectomized Rats
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Park Mi-Hwa
Kang Sung-Rim
Kim Mi-Hyang
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Abstract
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The aim of this study was to evaluate the effects of Codium fragile(CF) extract on the collagen content and collagen cross-link content of the connective tissues, alkaline phosphatase activity and calcium levels of serum in ovariectomized estrogen-deficient rats. Three groups were surgically ovariectomized. The fourth group was sham operated. Sprague-Dawley female rats were randomly assigned to the following groups : sham-operated rats(Sham), ovariectomized control rats (OVX-CON), ovariectomized rats supplemented with CF at 50 ㎎/㎏ body wt and 200 ㎎/㎏ body wt, respectively. The CF were orally administrated at 1mL a day. The ovariectomy caused a decreasing in collagen content in bone, cartilage, skin and lung tissues. However CF groups, supplementation with Codium fragile extract, increased in collagen content in bone and cartilage tissues than OVX-CON group. Pyridinoline content in cartilage collagen was decreased by ovariectomy but supplementation with the CF extracts was similarly increased to Sham. Alkaline phosphatase activity on serum of CF groups decreased than OVX-CON group. These results suggest that CF supplementation prevents post-menopausal bone loss, thus it may be used possibly to improve the quality of life in menopausal women.
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KEYWORD
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Collagen, pyridinoline, alkaline phosphatase, ovariectomized rat
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